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[edit] Mechanism of action
Although sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) all work by inhibiting PDE5, tadalafil's pharmacologic distinction is its longer half-life (17
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Sildenafil and vardenafil inhibit PDE6, an enzyme found in the eye, more than tadalafil
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Before taking CIALIS, tell your doctor about all your medical problems, particularly if you have or ever had:
* an allergy to CIALIS or ADCIRCA or any of its ingredients
* heart problems such as chest pain, heart failure, irregular heartbeats, or have had a heart attack
* high or low blood pressure
* stroke
* liver or kidney problems
* severe vision loss, including a condition called NAION
* retinitis pigmentosa, a rare genetic (runs in families) eye disease
* a deformed penis shape or Peyronie’s disease
* an erection that lasted more than 4 hours
* blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia
Can Other Medicines Affect CIALIS?
Tell your healthcare provider about all the medicines you take especially if you take:
* medicines called "nitrates" which are often prescribed for chest pain
* alpha blockers often prescribed for prostate problems
* blood pressure medications
* medicines for HIV or antifungal medications
* erythromycin
* other medicines or treatments for ED
* CIALIS is also marketed as ADCIRCA for the treatment of pulmonary arterial hypertension
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